Publications – Modeling Neurological Diseases using Stem Cells

Intoh A, Suzuki N, Koszka K, Eggan K. SLC52A3, A Brown-Vialetto-van Laere syndrome candidate gene is essential for mouse development, but dispensable for motor neuron differentiation. Hum Mol Genet. 2016 May 1;25(9):1814-23. doi: 10.1093/hmg/ddw053. PubMed PMID: 26976849; PubMed Central PMCID: PMC4986335.

Merkle FT, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier AF. Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development. 2015 Feb 15;142(4):633-43. doi: 10.1242/dev.117978. PubMed PMID: 25670790; PubMed Central PMCID: PMC4325380.

McNeish J, Gardner JP, Wainger BJ, Woolf CJ, Eggan K. From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial. Cell Stem Cell. 2015 Jul 2;17(1):8-10. doi: 10.1016/j.stem.2015.06.013. PubMed PMID: 26140603.

Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan;18(1):17-24. doi:10.1038/nn.3886. PubMed PMID: 25420066; PubMed Central PMCID: PMC4429606.

Koren A, Handsaker RE, Kamitaki N, Karlić R, Ghosh S, Polak P, Eggan K, McCarroll SA. Genetic variation in human DNA replication timing. Cell. 2014 Nov 20;159(5):1015-26. doi: 10.1016/j.cell.2014.10.025. PubMed PMID: 25416942; PubMed Central PMCID: PMC4359889.

Sandoe J, Eggan K. Opportunities and challenges of pluripotent stem cell neurodegenerative disease models. Nat Neurosci. 2013 Jul;16(7):780-9. doi:10.1038/nn.3425. Review. PubMed PMID: 23799470.

Merkle FT, Eggan K. Modeling human disease with pluripotent stem cells: from genome association to function. Cell Stem Cell. 2013 Jun 6;12(6):656-68. doi:10.1016/j.stem.2013.05.016. PubMed PMID: 23746975.

Maroof AM, Keros S, Tyson JA, Ying SW, Ganat YM, Merkle FT, Liu B, Goulburn A, Stanley EG, Elefanty AG, Widmer HR, Eggan K, Goldstein PA, Anderson SA, Studer Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell Stem Cell. 2013 May 2;12(5):559-72. doi: 10.1016/j.stem.2013.04.008. PubMed PMID: 23642365; PubMed Central PMCID: PMC3681523.

Williams LA, Davis-Dusenbery BN, Eggan KC. SnapShot: directed differentiation of pluripotent stem cells. Cell. 2012 May 25;149(5):1174-1174.e1. doi:10.1016/j.cell.2012.05.015. PubMed PMID: 22632979.

Davis-Dusenbery BN, Williams LA, Klim JR, Eggan K. How to make spinal motorneurons. Development. 2014 Feb;141(3):491-501. doi: 10.1242/dev.097410. Review.PubMed PMID: 24449832. Son EY, Ichida JK, Wainger BJ, Toma JS, Rafuse VF, Woolf CJ, Eggan K.Conversion of mouse and human fibroblasts into functional spinal motor neurons.Cell Stem Cell. 2011 Sep 2;9(3):205-18. doi: 10.1016/j.stem.2011.07.014. PubMedPMID: 21852222; PubMed Central PMCID: PMC3188987.

Han SS, Williams LA, Eggan KC. Constructing and deconstructing stem cellmodels of neurological disease. Neuron. 2011 May 26;70(4):626-44. doi:10.1016/j.neuron.2011.05.003. Review. PubMed PMID: 21609821.    Kiskinis E, Eggan K. Progress toward the clinical application ofpatient-specific pluripotent stem cells. J Clin Invest. 2010 Jan;120(1):51-9.doi: 10.1172/JCI40553. Review. PubMed PMID: 20051636; PubMed Central PMCID:PMC2798698.

Eggan K. Using stem cells and reprogramming to understand disease. Regen Med.2008 Nov;3(6):799-801. doi: 10.2217/17460751.3.6.799. PubMed PMID: 18947303.

ALS, Stem Cells and Neural Biology of Disease.